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» A co-evolutionary framework for regulatory motif discovery
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CEC
2007
IEEE
15 years 4 months ago
A co-evolutionary framework for regulatory motif discovery
Abstract— In previous work, we have shown how an evolutionary algorithm with a clustered population can be used to concurrently discover multiple regulatory motifs present within...
Michael A. Lones, Andy M. Tyrrell
BMCBI
2006
87views more  BMCBI 2006»
14 years 10 months ago
Phylogeny based discovery of regulatory elements
Background: Algorithms that locate evolutionarily conserved sequences have become powerful tools for finding functional DNA elements, including transcription factor binding sites;...
Jason Gertz, Justin C. Fay, Barak A. Cohen
BIBE
2007
IEEE
125views Bioinformatics» more  BIBE 2007»
15 years 4 months ago
Large-scale Discovery of Regulatory Motifs Involved in Alternative Splicing
Alternative splicing is a highly important process in many eukaryotic organisms, but surprisingly little is known about its regulation. Often, this process involves cis-regulatory ...
Sihui Zhao, Jihye Kim, Steffen Heber
ALMOB
2006
138views more  ALMOB 2006»
14 years 10 months ago
A combinatorial optimization approach for diverse motif finding applications
Background: Discovering approximately repeated patterns, or motifs, in biological sequences is an important and widely-studied problem in computational molecular biology. Most fre...
Elena Zaslavsky, Mona Singh
BMCBI
2007
148views more  BMCBI 2007»
14 years 10 months ago
WeederH: an algorithm for finding conserved regulatory motifs and regions in homologous sequences
Background: This work addresses the problem of detecting conserved transcription factor binding sites and in general regulatory regions through the analysis of sequences from homo...
Giulio Pavesi, Federico Zambelli, Graziano Pesole