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» A polyhedral approach to sequence alignment problems
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CPM
1993
Springer
154views Combinatorics» more  CPM 1993»
15 years 1 months ago
On Suboptimal Alignments of Biological Sequences
It is widely accepted that the optimal alignment between a pair of proteins or nucleic acid sequences that minimizes the edit distance may not necessarily re ect the correct biolog...
Dalit Naor, Douglas L. Brutlag
88
Voted
BMEI
2008
IEEE
15 years 4 months ago
A New Approach for Tree Alignment Based on Local Re-Optimization
Multiple sequence alignment is the most fundamental task in bioinformatics and computational biology. In this paper, we present a new algorithm to conduct multiple sequences align...
Feng Yue, Jijun Tang
GCB
2006
Springer
140views Biometrics» more  GCB 2006»
15 years 1 months ago
PALMA: Perfect Alignments using Large Margin Algorithms
: Despite many years of research on how to properly align sequences in the presence of sequencing errors, alternative splicing and micro-exons, the correct alignment of mRNA sequen...
Gunnar Rätsch, Bettina Hepp, Uta Schulze, Che...
IDA
2007
Springer
15 years 3 months ago
Learning to Align: A Statistical Approach
We present a new machine learning approach to the inverse parametric sequence alignment problem: given as training examples a set of correct pairwise global alignments, find the p...
Elisa Ricci, Tijl De Bie, Nello Cristianini
BMCBI
2005
122views more  BMCBI 2005»
14 years 9 months ago
Bayesian coestimation of phylogeny and sequence alignment
Background: Two central problems in computational biology are the determination of the alignment and phylogeny of a set of biological sequences. The traditional approach to this p...
Gerton Lunter, István Miklós, Alexei...