77 search results - page 11 / 16 » A structural keystone for drug design |
ISBI
2002
IEEE
16 years 11 days ago
2002
IEEE
We describe the Protein Subcellular Location Image Database (PSLID), which collects and structures 2-D through 5-D fluorescence microscope images, annotations, and derived feature...
110
click to vote
BMCBI
2008
14 years 11 months ago
2008
Background: Biological chemistry is very stereospecific. Nonetheless, the diastereotopic oxygen atoms of diphosphate-containing molecules in the Protein Data Bank (PDB) are often ...
91
Voted
GRID
2007
Springer
15 years 5 months ago
2007
Springer
— Replica exchange is a powerful sampling algorithm and can be effectively used for applications such as simulating the structure, function, folding, and dynamics of proteins and...
89
Voted
GECCO
2003
Springer
15 years 4 months ago
2003
Springer
We have developed an evolutionary approach for the flexible docking that is now an important component of a rational drug design. This automatic docking tool, referred to as the G...
85
Voted
BIRD
2008
Springer
15 years 1 months ago
2008
Springer
The inverse protein folding problem is that of designing an amino acid sequence which has a prescribed native protein fold. This problem arises in drug design where a particular st...