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» About the use of protein models
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BMCBI
2006
249views more  BMCBI 2006»
15 years 1 months ago
Gene functional similarity search tool (GFSST)
Background: With the completion of the genome sequences of human, mouse, and other species and the advent of high throughput functional genomic research technologies such as biomi...
Peisen Zhang, Jinghui Zhang, Huitao Sheng, James J...
BIBM
2009
IEEE
155views Bioinformatics» more  BIBM 2009»
15 years 8 months ago
Towards Reliable Isoform Quantification Using RNA-Seq Data
Background: In eukaryotes, alternative splicing often generates multiple splice variants from a single gene. Here weexplore the use of RNA sequencing (RNA-Seq) datasets to address...
Brian E. Howard, Steffen Heber
ATAL
2008
Springer
15 years 3 months ago
Selecting strategies using empirical game models: an experimental analysis of meta-strategies
In many complex multi-agent domains it is impractical to compute exact analytic solutions. An alternate means of analysis applies computational tools to derive and analyze empiric...
Christopher Kiekintveld, Michael P. Wellman
122
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ALMOB
2006
106views more  ALMOB 2006»
15 years 1 months ago
Multiple sequence alignment with user-defined anchor points
Background: Automated software tools for multiple alignment often fail to produce biologically meaningful results. In such situations, expert knowledge can help to improve the qua...
Burkhard Morgenstern, Sonja J. Prohaska, Dirk P&ou...
104
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JAMIA
2011
94views more  JAMIA 2011»
14 years 4 months ago
Protein-network modeling of prostate cancer gene signatures reveals essential pathways in disease recurrence
Objective Uncovering the dominant molecular deregulation among the multitude of pathways implicated in aggressive prostate cancer is essential to intelligently developing targeted...
James L. Chen, Jianrong Li, Walter M. Stadler, Yve...