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CIKM
2009
Springer
15 years 8 months ago
MKEM: a multi-level knowledge emergence model for mining undiscovered public knowledge
Background: Since Swanson proposed the Undiscovered Public Knowledge (UPK) model, there have been many approaches to uncover UPK by mining the biomedical literature. These earlier...
Ali Zeeshan Ijaz, Min Song, Doheon Lee
BMCBI
2007
186views more  BMCBI 2007»
15 years 1 months ago
Modeling human cancer-related regulatory modules by GA-RNN hybrid algorithms
Background: Modeling cancer-related regulatory modules from gene expression profiling of cancer tissues is expected to contribute to our understanding of cancer biology as well as...
Jung-Hsien Chiang, Shih-Yi Chao
BMCBI
2010
135views more  BMCBI 2010»
15 years 2 months ago
Quadratic variance models for adaptively preprocessing SELDI-TOF mass spectrometry data
Background: Surface enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI) is a proteomics tool for biomarker discovery and other high throughput applicatio...
Vincent A. Emanuele II, Brian M. Gurbaxani
114
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JCNS
2000
73views more  JCNS 2000»
15 years 1 months ago
Models of Calmodulin Trapping and CaM Kinase II Activation in a Dendritic Spine
Activation of calcium/calmodulin-dependent protein kinase II (CaMKII) by calmodulin following calcium entry into the cell is important for long-term potentiation (LTP). Here a mode...
William Holmes
JCB
2007
198views more  JCB 2007»
15 years 1 months ago
Bayesian Hierarchical Model for Large-Scale Covariance Matrix Estimation
Many bioinformatics problems can implicitly depend on estimating large-scale covariance matrix. The traditional approaches tend to give rise to high variance and low accuracy esti...
Dongxiao Zhu, Alfred O. Hero III