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BMCBI
2007
122views more  BMCBI 2007»
15 years 6 months ago
TAP score: torsion angle propensity normalization applied to local protein structure evaluation
Background: Experimentally determined protein structures may contain errors and require validation. Conformational criteria based on the Ramachandran plot are mainly used to disti...
Silvio C. E. Tosatto, Roberto Battistutta
BMCBI
2008
115views more  BMCBI 2008»
15 years 6 months ago
Probe signal correction for differential methylation hybridization experiments
Background: Non-biological signal (or noise) has been the bane of microarray analysis. Hybridization effects related to probe-sequence composition and DNA dye-probe interactions h...
Dustin P. Potter, Pearlly Yan, Tim Hui-Ming Huang,...
BMCBI
2008
149views more  BMCBI 2008»
15 years 6 months ago
Evolution of biological sequences implies an extreme value distribution of type I for both global and local pairwise alignment s
Background: Confidence in pairwise alignments of biological sequences, obtained by various methods such as Blast or Smith-Waterman, is critical for automatic analyses of genomic d...
Olivier Bastien, Eric Maréchal
ALIFE
2006
15 years 6 months ago
Genetic Stability and Territorial Structure Facilitate the Evolution of Tag-Mediated Altruism
Evolutionary theorists have long been interested in the conditions that permit the evolution of altruistic cooperation. Recent work has demonstrated that altruistic donation can ev...
Lee Spector, Jon Klein
BMCBI
2006
137views more  BMCBI 2006»
15 years 6 months ago
A maximum likelihood framework for protein design
Background: The aim of protein design is to predict amino-acid sequences compatible with a given target structure. Traditionally envisioned as a purely thermodynamic question, thi...
Claudia L. Kleinman, Nicolas Rodrigue, Céci...