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CIBB
2008
14 years 11 months ago
Unsupervised Stability-Based Ensembles to Discover Reliable Structures in Complex Bio-molecular Data
The assessment of the reliability of clusters discovered in bio-molecular data is a central issue in several bioinformatics problems. Several methods based on the concept of stabil...
Alberto Bertoni, Giorgio Valentini
BMCBI
2007
134views more  BMCBI 2007»
14 years 9 months ago
Nearest Neighbor Networks: clustering expression data based on gene neighborhoods
Background: The availability of microarrays measuring thousands of genes simultaneously across hundreds of biological conditions represents an opportunity to understand both indiv...
Curtis Huttenhower, Avi I. Flamholz, Jessica N. La...
BMCBI
2008
142views more  BMCBI 2008»
14 years 9 months ago
Genetic weighted k-means algorithm for clustering large-scale gene expression data
Background: The traditional (unweighted) k-means is one of the most popular clustering methods for analyzing gene expression data. However, it suffers three major shortcomings. It...
Fang-Xiang Wu
BMCBI
2008
259views more  BMCBI 2008»
14 years 9 months ago
DISCLOSE : DISsection of CLusters Obtained by SEries of transcriptome data using functional annotations and putative transcripti
Background: A typical step in the analysis of gene expression data is the determination of clusters of genes that exhibit similar expression patterns. Researchers are confronted w...
Evert-Jan Blom, Sacha A. F. T. van Hijum, Klaas J....
BIOINFORMATICS
2007
195views more  BIOINFORMATICS 2007»
14 years 9 months ago
Context-dependent clustering for dynamic cellular state modeling of microarray gene expression
Motivation: High-throughput expression profiling allows researchers to study gene activities globally. Genes with similar expression profiles are likely to encode proteins that ma...
Shinsheng Yuan, Ker-Chau Li