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» Computational Challenges of Systems Biology
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BMCBI
2010
110views more  BMCBI 2010»
14 years 9 months ago
Discovering local patterns of co - evolution: computational aspects and biological examples
Background: Co-evolution is the process in which two (or more) sets of orthologs exhibit a similar or correlative pattern of evolution. Co-evolution is a powerful way to learn abo...
Tamir Tuller, Yifat Felder, Martin Kupiec
ALMOB
2006
110views more  ALMOB 2006»
14 years 9 months ago
Computing distribution of scale independent motifs in biological sequences
The use of Chaos Game Representation (CGR) or its generalization, Universal Sequence Maps (USM), to describe the distribution of biological sequences has been found objectionable ...
Jonas S. Almeida, Susana Vinga
ICSE
2005
IEEE-ACM
15 years 9 months ago
Research challenges of autonomic computing
Autonomic computing is a grand-challenge vision of the future in which computing systems will manage themselves in accordance with high-level objectives specified by humans. The I...
Jeffrey O. Kephart
DEXA
2007
Springer
150views Database» more  DEXA 2007»
15 years 3 months ago
Sequence Alignment as a Database Technology Challenge
Abstract. Sequence alignment is an important task for molecular biologists. Because alignment basically deals with approximate string matching on large biological sequence collecti...
Hans Philippi
SIGMOD
2012
ACM
275views Database» more  SIGMOD 2012»
13 years 3 days ago
Computational reproducibility: state-of-the-art, challenges, and database research opportunities
Computational experiments have become an integral part of the scientific method, but reproducing, archiving, and querying them is still a challenge. The first barrier to a wider...
Juliana Freire, Philippe Bonnet, Dennis Shasha