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BMCBI
2010
139views more  BMCBI 2010»
15 years 15 days ago
A global optimization algorithm for protein surface alignment
Background: A relevant problem in drug design is the comparison and recognition of protein binding sites. Binding sites recognition is generally based on geometry often combined w...
Paola Bertolazzi, Concettina Guerra, Giampaolo Liu...
113
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BMCBI
2010
164views more  BMCBI 2010»
15 years 15 days ago
Investigating the validity of current network analysis on static conglomerate networks by protein network stratification
Background: A molecular network perspective forms the foundation of systems biology. A common practice in analyzing protein-protein interaction (PPI) networks is to perform networ...
Minlu Zhang, Long J. Lu
106
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BMCBI
2008
135views more  BMCBI 2008»
15 years 15 days ago
Knowledge-guided multi-scale independent component analysis for biomarker identification
Background: Many statistical methods have been proposed to identify disease biomarkers from gene expression profiles. However, from gene expression profile data alone, statistical...
Li Chen, Jianhua Xuan, Chen Wang, Ie-Ming Shih, Yu...
ALGORITHMICA
2006
139views more  ALGORITHMICA 2006»
15 years 14 days ago
CONQUEST: A Coarse-Grained Algorithm for Constructing Summaries of Distributed Discrete Datasets
Abstract. In this paper we present a coarse-grained parallel algorithm, CONQUEST, for constructing boundederror summaries of high-dimensional binary attributed data in a distribute...
Jie Chi, Mehmet Koyutürk, Ananth Grama
BMCBI
2006
171views more  BMCBI 2006»
15 years 14 days ago
The effect of oligonucleotide microarray data pre-processing on the analysis of patient-cohort studies
Background: Intensity values measured by Affymetrix microarrays have to be both normalized, to be able to compare different microarrays by removing non-biological variation, and s...
Roel G. W. Verhaak, Frank J. T. Staal, Peter J. M....