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BMCBI
2010
133views more  BMCBI 2010»
14 years 12 months ago
Predicting enzyme targets for cancer drugs by profiling human Metabolic reactions in NCI-60 cell lines
Background: Drugs can influence the whole metabolic system by targeting enzymes which catalyze metabolic reactions. The existence of interactions between drugs and metabolic react...
Limin Li, Xiaobo Zhou, Wai-Ki Ching, Ping Wang
CORR
2010
Springer
152views Education» more  CORR 2010»
14 years 12 months ago
Neuroevolutionary optimization
Temporal difference methods are theoretically grounded and empirically effective methods for addressing reinforcement learning problems. In most real-world reinforcement learning ...
Eva Volná
ALMOB
2006
138views more  ALMOB 2006»
14 years 12 months ago
A combinatorial optimization approach for diverse motif finding applications
Background: Discovering approximately repeated patterns, or motifs, in biological sequences is an important and widely-studied problem in computational molecular biology. Most fre...
Elena Zaslavsky, Mona Singh
ALMOB
2006
155views more  ALMOB 2006»
14 years 12 months ago
Refining motifs by improving information content scores using neighborhood profile search
The main goal of the motif finding problem is to detect novel, over-represented unknown signals in a set of sequences (e.g. transcription factor binding sites in a genome). The mo...
Chandan K. Reddy, Yao-Chung Weng, Hsiao-Dong Chian...
JAIR
2008
93views more  JAIR 2008»
14 years 12 months ago
Spectrum of Variable-Random Trees
In this paper, we show that a continuous spectrum of randomisation exists, in which most existing tree randomisations are only operating around the two ends of the spectrum. That ...
Fei Tony Liu, Kai Ming Ting, Yang Yu, Zhi-Hua Zhou