Background: In order to improve gene prediction, extrinsic evidence on the gene structure can be collected from various sources of information such as genome-genome comparisons an...
Background: The PD-(D/E)XK nuclease superfamily, initially identified in type II restriction endonucleases and later in many enzymes involved in DNA recombination and repair, is o...
In this paper, westudy the application of an ttMM(hidden Markov model) to the problem of representing protein sequencesby a stochastic motif. Astochastic protein motif represents ...
Background: An important challenge in eukaryotic gene prediction is accurate identification of alternatively spliced exons. Functional transcripts can go undetected in gene expres...
One of the major limitations of HMM-based models is the inability to cope with topology: When applied to a visible observation (VO) sequence, HMM-based techniques have difficulty ...