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ECCB
2002
IEEE
15 years 4 months ago
Stochastic roadmap simulation for the study of ligand-protein interactions
The dynamics of ligand-protein interactions are necessary to understand for the design of novel therapeutic agents. In this paper, we establish the use of Stochastic Roadmap Simul...
Mehmet Serkan Apaydin, Carlos Guestrin, Chris Varm...
BMCBI
2008
200views more  BMCBI 2008»
14 years 12 months ago
Defining functional distances over Gene Ontology
Background: A fundamental problem when trying to define the functional relationships between proteins is the difficulty in quantifying functional similarities, even when well-stru...
Angela del Pozo, Florencio Pazos, Alfonso Valencia
BMCBI
2008
121views more  BMCBI 2008»
14 years 12 months ago
GeneTrailExpress: a web-based pipeline for the statistical evaluation of microarray experiments
Background: High-throughput methods that allow for measuring the expression of thousands of genes or proteins simultaneously have opened new avenues for studying biochemical proce...
Andreas Keller, Christina Backes, Maher Al-Awadhi,...
BMCBI
2006
101views more  BMCBI 2006»
14 years 12 months ago
SynTReN: a generator of synthetic gene expression data for design and analysis of structure learning algorithms
Background: The development of algorithms to infer the structure of gene regulatory networks based on expression data is an important subject in bioinformatics research. Validatio...
Tim Van den Bulcke, Koen Van Leemput, Bart Naudts,...
RECOMB
2005
Springer
16 years 3 days ago
Improved Duplication Models for Proteome Network Evolution
Protein-protein interaction networks, particularly that of the yeast S. Cerevisiae, have recently been studied extensively. These networks seem to satisfy the small world property ...
Gürkan Bebek, Petra Berenbrink, Colin Cooper,...