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BMCBI
2010
150views more  BMCBI 2010»
15 years 4 months ago
Systematic calibration of a cell signaling network model
Background: Mathematical modeling is being applied to increasingly complex biological systems and datasets; however, the process of analyzing and calibrating against experimental ...
Kyoung Ae Kim, Sabrina L. Spencer, John G. Albeck,...
BMCBI
2010
152views more  BMCBI 2010»
15 years 4 months ago
Comparative study of three commonly used continuous deterministic methods for modeling gene regulation networks
Background: A gene-regulatory network (GRN) refers to DNA segments that interact through their RNA and protein products and thereby govern the rates at which genes are transcribed...
Martin T. Swain, Johannes J. Mandel, Werner Dubitz...
BMCBI
2008
147views more  BMCBI 2008»
15 years 4 months ago
Transmembrane helix prediction using amino acid property features and latent semantic analysis
Background: Prediction of transmembrane (TM) helices by statistical methods suffers from lack of sufficient training data. Current best methods use hundreds or even thousands of f...
Madhavi Ganapathiraju, Narayanas Balakrishnan, Raj...
DCG
2010
289views more  DCG 2010»
15 years 4 months ago
Algorithms for Approximate Shortest Path Queries on Weighted Polyhedral Surfaces
We consider the well known geometric problem of determining shortest paths between pairs of points on a polyhedral surface P, where P consists of triangular faces with positive we...
Lyudmil Aleksandrov, Hristo Djidjev, Hua Guo, Anil...
BMCBI
2006
147views more  BMCBI 2006»
15 years 4 months ago
A case study in pathway knowledgebase verification
Background: Biological databases and pathway knowledgebases are proliferating rapidly. We are developing software tools for computer-aided hypothesis design and evaluation, and we...
Stephen A. Racunas, Nigam Shah, Nina V. Fedoroff