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BIOINFORMATICS
2006
92views more  BIOINFORMATICS 2006»
14 years 12 months ago
What should be expected from feature selection in small-sample settings
Motivation: High-throughput technologies for rapid measurement of vast numbers of biological variables offer the potential for highly discriminatory diagnosis and prognosis; howev...
Chao Sima, Edward R. Dougherty
BMCBI
2006
195views more  BMCBI 2006»
14 years 12 months ago
Hubs of knowledge: using the functional link structure in Biozon to mine for biologically significant entities
Background: Existing biological databases support a variety of queries such as keyword or definition search. However, they do not provide any measure of relevance for the instance...
Paul Shafer, Timothy Isganitis, Golan Yona
BMCBI
2006
123views more  BMCBI 2006»
14 years 12 months ago
An Automated Method for Rapid Identification of Putative Gene Family Members in Plants
Background: Gene duplication events have played a significant role in genome evolution, particularly in plants. Exhaustive searches for all members of a known gene family as well ...
Ronald L. Frank, Ajay Mane, Fikret Erçal
BMCBI
2006
95views more  BMCBI 2006»
14 years 12 months ago
Discrete profile comparison using information bottleneck
Sequence homologs are an important source of information about proteins. Amino acid profiles, representing the position-specific mutation probabilities found in profiles, are a ri...
Sean O'Rourke, Gal Chechik, Robin Friedman, Eleaza...
BMCBI
2006
103views more  BMCBI 2006»
14 years 12 months ago
Cis-motifs upstream of the transcription and translation initiation sites are effectively revealed by their positional disequili
Background: The discovery of cis-regulatory motifs still remains a challenging task even though the number of sequenced genomes is constantly growing. Computational analyses using...
Kenneth W. Berendzen, Kurt Stüber, Klaus Hart...