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BMCBI
2010
160views more  BMCBI 2010»
14 years 9 months ago
Quantitative model for inferring dynamic regulation of the tumour suppressor gene p53
Background: The availability of various "omics" datasets creates a prospect of performing the study of genomewide genetic regulatory networks. However, one of the major ...
Junbai Wang, Tianhai Tian
BMCBI
2006
203views more  BMCBI 2006»
14 years 9 months ago
Genome-wide prediction of transcriptional regulatory elements of human promoters using gene expression and promoter analysis dat
Background: A complete understanding of the regulatory mechanisms of gene expression is the next important issue of genomics. Many bioinformaticians have developed methods and alg...
Seon-Young Kim, YongSung Kim
GECCO
2005
Springer
127views Optimization» more  GECCO 2005»
15 years 2 months ago
Identifying valid solutions for the inference of regulatory networks
In this paper, we address the problem of finding gene regulatory networks from experimental DNA microarray data. The problem often is multi-modal and therefore appropriate optimi...
Christian Spieth, Felix Streichert, Nora Speer, An...
BIRD
2008
Springer
141views Bioinformatics» more  BIRD 2008»
14 years 11 months ago
Nested q-Partial Graphs for Genetic Network Inference from "Small n, Large p" Microarray Data
Abstract. Gaussian graphical models are widely used to tackle the important and challenging problem of inferring genetic regulatory networks from expression data. These models have...
Kevin Kontos, Gianluca Bontempi
BMCBI
2005
178views more  BMCBI 2005»
14 years 9 months ago
A quantization method based on threshold optimization for microarray short time series
Background: Reconstructing regulatory networks from gene expression profiles is a challenging problem of functional genomics. In microarray studies the number of samples is often ...
Barbara Di Camillo, Fatima Sanchez-Cabo, Gianna To...