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BMCBI
2008
84views more  BMCBI 2008»
14 years 10 months ago
Prediction of specificity-determining residues for small-molecule kinase inhibitors
Background: Designing small-molecule kinase inhibitors with desirable selectivity profiles is a major challenge in drug discovery. A high-throughput screen for inhibitors of a giv...
Daniel R. Caffrey, Elizabeth A. Lunney, Deborah J....
BMCBI
2006
145views more  BMCBI 2006»
14 years 10 months ago
GEM System: automatic prototyping of cell-wide metabolic pathway models from genomes
Background: Successful realization of a "systems biology" approach to analyzing cells is a grand challenge for our understanding of life. However, current modeling appro...
Kazuharu Arakawa, Yohei Yamada, Kosaku Shinoda, Yo...
TCBB
2008
137views more  TCBB 2008»
14 years 10 months ago
Toward Verified Biological Models
The last several decades have witnessed a vast accumulation of biological data and data analysis. Many of these data sets represent only a small fraction of the system's behav...
Avital Sadot, Jasmin Fisher, Dan Barak, Yishai Adm...
JSS
2008
122views more  JSS 2008»
14 years 8 months ago
Traffic-aware stress testing of distributed real-time systems based on UML models using genetic algorithms
This report presents a model-driven, stress test methodology aimed at increasing chances of discovering faults related to network traffic in Distributed Real-Time Systems (DRTS). T...
Vahid Garousi, Lionel C. Briand, Yvan Labiche
105
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CGF
2011
14 years 1 months ago
Visual Exploration of Time-Series Data with Shape Space Projections
Time-series data is a common target for visual analytics, as they appear in a wide range of application domains. Typical tasks in analyzing time-series data include identifying cy...
Matthew O. Ward, Zhenyu Guo