Background: In the analysis of networks we frequently require the statistical significance of some network statistic, such as measures of similarity for the properties of interact...
Background: Comparison of large protein datasets has become a standard task in bioinformatics. Typically researchers wish to know whether one group of proteins is significantly en...
Optimization problems are typically addressed by purely automatic approaches. For multi-objective problems, however, a single best solution often does not exist. In this case, it ...
The 3D Morse-Smale complex is a fundamental topological construct that partitions the domain of a real-valued function into regions having uniform gradient flow behavior. In this...
Discovering co-expressed genes and coherent expression patterns in gene expression data is an important data analysis task in bioinformatics research and biomedical applications. ...