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128
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BMCBI
2008
93views more  BMCBI 2008»
15 years 4 months ago
Homology modelling of protein-protein complexes: a simple method and its possibilities and limitations
Background: Structure-based computational methods are needed to help identify and characterize protein-protein complexes and their function. For individual proteins, the most succ...
Guillaume Launay, Thomas Simonson
147
Voted
BMCBI
2008
121views more  BMCBI 2008»
15 years 4 months ago
Stability of gene contributions and identification of outliers in multivariate analysis of microarray data
Background: Multivariate ordination methods are powerful tools for the exploration of complex data structures present in microarray data. These methods have several advantages com...
Florent Baty, Daniel Jaeger, Frank Preiswerk, Mart...
139
Voted
BMCBI
2008
123views more  BMCBI 2008»
15 years 4 months ago
A tree-based conservation scoring method for short linear motifs in multiple alignments of protein sequences
Background: The structure of many eukaryotic cell regulatory proteins is highly modular. They are assembled from globular domains, segments of natively disordered polypeptides and...
Claudia Chica, Alberto Labarga, Cathryn M. Gould, ...
BMCBI
2008
136views more  BMCBI 2008»
15 years 4 months ago
An efficient method for the prediction of deleterious multiple-point mutations in the secondary structure of RNAs using suboptim
Background: RNAmute is an interactive Java application which, given an RNA sequence, calculates the secondary structure of all single point mutations and organizes them into categ...
Alexander Churkin, Danny Barash
BMCBI
2008
226views more  BMCBI 2008»
15 years 4 months ago
ProteoLens: a visual analytic tool for multi-scale database-driven biological network data mining
Background: New systems biology studies require researchers to understand how interplay among myriads of biomolecular entities is orchestrated in order to achieve high-level cellu...
Tianxiao Huan, Andrey Y. Sivachenko, Scott H. Harr...
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