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140
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BMCBI
2007
148views more  BMCBI 2007»
15 years 3 months ago
fREDUCE: Detection of degenerate regulatory elements using correlation with expression
Background: The precision of transcriptional regulation is made possible by the specificity of physical interactions between transcription factors and their cognate binding sites ...
Randy Z. Wu, Christina Chaivorapol, Jiashun Zheng,...
BMCBI
2005
98views more  BMCBI 2005»
15 years 3 months ago
The effects of normalization on the correlation structure of microarray data
Background: Stochastic dependence between gene expression levels in microarray data is of critical importance for the methods of statistical inference that resort to pooling test-...
Xing Qiu, Andrew I. Brooks, Lev Klebanov, Andrei Y...
141
Voted
BIOINFORMATICS
2007
195views more  BIOINFORMATICS 2007»
15 years 3 months ago
Context-dependent clustering for dynamic cellular state modeling of microarray gene expression
Motivation: High-throughput expression profiling allows researchers to study gene activities globally. Genes with similar expression profiles are likely to encode proteins that ma...
Shinsheng Yuan, Ker-Chau Li
BMCBI
2004
142views more  BMCBI 2004»
15 years 3 months ago
GOTree Machine (GOTM): a web-based platform for interpreting sets of interesting genes using Gene Ontology hierarchies
Background: Microarray and other high-throughput technologies are producing large sets of interesting genes that are difficult to analyze directly. Bioinformatics tools are needed...
Bing Zhang, Denise Schmoyer, Stefan Kirov, Jay Sno...
125
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RECOMB
2005
Springer
16 years 4 months ago
Causal Inference of Regulator-Target Pairs by Gene Mapping of Expression Phenotypes
Background: Correlations between polymorphic markers and observed phenotypes provide the basis for mapping traits in quantitative genetics. When the phenotype is gene expression, ...
David Kulp, Manjunatha Jagalur