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» Learning Methods for DNA Binding in Computational Biology
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90
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BMCBI
2005
102views more  BMCBI 2005»
14 years 9 months ago
Genome-wide identification of the regulatory targets of a transcription factor using biochemical characterization and computatio
Background: A major challenge in computational genomics is the development of methodologies that allow accurate genome-wide prediction of the regulatory targets of a transcription...
Emmitt R. Jolly, Chen-Shan Chin, Ira Herskowitz, H...
61
Voted
BMCBI
2010
116views more  BMCBI 2010»
14 years 9 months ago
Predicting success of oligomerized pool engineering (OPEN) for zinc finger target site sequences
Background: Precise and efficient methods for gene targeting are critical for detailed functional analysis of genomes and regulatory networks and for potentially improving the eff...
Jeffry D. Sander, Deepak Reyon, Morgan L. Maeder, ...
BMCBI
2007
128views more  BMCBI 2007»
14 years 9 months ago
A robust and efficient algorithm for the shape description of protein structures and its application in predicting ligand bindin
Background: An accurate description of protein shape derived from protein structure is necessary to establish an understanding of protein-ligand interactions, which in turn will l...
Lei Xie, Philip E. Bourne
BICOB
2010
Springer
15 years 2 months ago
Algebraic Theory of DNA Recombination
In this paper we investigate the structure and representation of n-ary algebras arising from DNA recombination, where n is a number of DNA segments participating in recombination. ...
Sergei R. Sverchkov
108
Voted
BMCBI
2008
214views more  BMCBI 2008»
14 years 8 months ago
Enhanced Bayesian modelling in BAPS software for learning genetic structures of populations
Background: During the most recent decade many Bayesian statistical models and software for answering questions related to the genetic structure underlying population samples have...
Jukka Corander, Pekka Marttinen, Jukka Siré...