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BMCBI
2008
110views more  BMCBI 2008»
14 years 11 months ago
Methylation Linear Discriminant Analysis (MLDA) for identifying differentially methylated CpG islands
Background: Hypermethylation of promoter CpG islands is strongly correlated to transcriptional gene silencing and epigenetic maintenance of the silenced state. As well as its role...
Wei Dai, Jens M. Teodoridis, Janet Graham, Constan...
BMCBI
2008
102views more  BMCBI 2008»
14 years 11 months ago
Ornithine decarboxylase antizyme finder (OAF): Fast and reliable detection of antizymes with frameshifts in mRNAs
Background: Ornithine decarboxylase antizymes are proteins which negatively regulate cellular polyamine levels via their affects on polyamine synthesis and cellular uptake. In vir...
Michaël Bekaert, Ivaylo P. Ivanov, John F. At...
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BMCBI
2008
80views more  BMCBI 2008»
14 years 11 months ago
Computational evaluation of TIS annotation for prokaryotic genomes
Background: Accurate annotation of translation initiation sites (TISs) is essential for understanding the translation initiation mechanism. However, the reliability of TIS annotat...
Gang-Qing Hu, Xiaobin Zheng, Li-Ning Ju, Huaiqiu Z...
CORR
2010
Springer
83views Education» more  CORR 2010»
14 years 11 months ago
Swapping Evaluation: A Memory-Scalable Solution for Answer-On-Demand Tabling
One of the differences among the various approaches to suspension-based tabled evaluation is the scheduling strategy. The two most popular strategies are local and batched evaluat...
Pablo Chico de Guzmán, Manuel Carro, David ...
ALMOB
2006
155views more  ALMOB 2006»
14 years 11 months ago
A phylogenetic generalized hidden Markov model for predicting alternatively spliced exons
Background: An important challenge in eukaryotic gene prediction is accurate identification of alternatively spliced exons. Functional transcripts can go undetected in gene expres...
Jonathan E. Allen, Steven L. Salzberg