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» Logic-Based Modeling in Systems Biology
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ISCAS
2006
IEEE
162views Hardware» more  ISCAS 2006»
15 years 5 months ago
Silicon neurons that phase-lock
Abstract—We present a silicon neuron with a dynamic, active leak that enables precise spike-timing with respect to a time-varying input signal. Our neuron models the mammalian bu...
J. H. Wittig Jr., Kwabena Boahen
BMCBI
2006
175views more  BMCBI 2006»
14 years 12 months ago
Parameter estimation for stiff equations of biosystems using radial basis function networks
Background: The modeling of dynamic systems requires estimating kinetic parameters from experimentally measured time-courses. Conventional global optimization methods used for par...
Yoshiya Matsubara, Shinichi Kikuchi, Masahiro Sugi...
RECOMB
2006
Springer
16 years 3 days ago
Genome-Wide Discovery of Modulators of Transcriptional Interactions in Human B Lymphocytes
Abstract. Transcriptional interactions in a cell are modulated by a variety of mechanisms that prevent their representation as pure pairwise interactions between a transcription fa...
Kai Wang, Ilya Nemenman, Nilanjana Banerjee, Adam ...
NAR
2011
374views Computer Vision» more  NAR 2011»
14 years 6 months ago
The BioGRID Interaction Database: 2011 update
The Biological General Repository for Interaction Datasets (BioGRID) is a public database that archives and disseminates genetic and protein interaction data from model organisms ...
Chris Stark, Bobby-Joe Breitkreutz, Andrew Chatr-a...
BMCBI
2007
146views more  BMCBI 2007»
14 years 12 months ago
Spatial location and its relevance for terminological inferences in bio-ontologies
Background: An adequate and expressive ontological representation of biological organisms and their parts requires formal reasoning mechanisms for their relations of physical aggr...
Stefan Schulz, Kornél G. Markó, Udo ...