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» Microarray Gene Expression Data Analysis
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BMCBI
2008
110views more  BMCBI 2008»
14 years 9 months ago
Methylation Linear Discriminant Analysis (MLDA) for identifying differentially methylated CpG islands
Background: Hypermethylation of promoter CpG islands is strongly correlated to transcriptional gene silencing and epigenetic maintenance of the silenced state. As well as its role...
Wei Dai, Jens M. Teodoridis, Janet Graham, Constan...
BMCBI
2005
104views more  BMCBI 2005»
14 years 9 months ago
A statistical approach for array CGH data analysis
Background: Microarray-CGH experiments are used to detect and map chromosomal imbalances, by hybridizing targets of genomic DNA from a test and a reference sample to sequences imm...
Franck Picard, Stéphane Robin, Marc Laviell...
IMSCCS
2006
IEEE
15 years 3 months ago
Combining Comparative Genomics with de novo Motif Discovery to Identify Human Transcription Factor DNA-Binding Motifs
Background: As more and more genomes are sequenced, comparative genomics approaches provide a methodology for identifying conserved regulatory elements that may be involved in gen...
Linyong Mao, W. Jim Zheng
CVPR
2008
IEEE
15 years 11 months ago
A unified framework for generalized Linear Discriminant Analysis
Linear Discriminant Analysis (LDA) is one of the wellknown methods for supervised dimensionality reduction. Over the years, many LDA-based algorithms have been developed to cope w...
Shuiwang Ji, Jieping Ye
101
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TNN
2008
105views more  TNN 2008»
14 years 9 months ago
Generalized Linear Discriminant Analysis: A Unified Framework and Efficient Model Selection
Abstract--High-dimensional data are common in many domains, and dimensionality reduction is the key to cope with the curse-of-dimensionality. Linear discriminant analysis (LDA) is ...
Shuiwang Ji, Jieping Ye