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» Mining Gene Expression Data using Domain Knowledge
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BMCBI
2010
144views more  BMCBI 2010»
15 years 2 months ago
Identifying overrepresented concepts in gene lists from literature: a statistical approach based on Poisson mixture model
Background: Large-scale genomic studies often identify large gene lists, for example, the genes sharing the same expression patterns. The interpretation of these gene lists is gen...
Xin He, Moushumi Sen Sarma, Xu Ling, Brant W. Chee...
CBMS
2007
IEEE
15 years 8 months ago
Auto-Extraction, Representation and Integration of a Diabetes Ontology Using Bayesian Networks
This paper describes how high level biological knowledge obtained from ontologies such as the Gene Ontology (GO) can be integrated with low level information extracted from a Baye...
Kenneth McGarry, Sheila Garfield, Stefan Wermter
WABI
2009
Springer
124views Bioinformatics» more  WABI 2009»
15 years 8 months ago
Mimosa: Mixture Model of Co-expression to Detect Modulators of Regulatory Interaction
Background: Functionally related genes tend to be correlated in their expression patterns across multiple conditions and/or tissue-types. Thus co-expression networks are often use...
Matthew Hansen, Logan Everett, Larry Singh, Sridha...
DEXAW
2005
IEEE
189views Database» more  DEXAW 2005»
15 years 7 months ago
Knowledge Management Challenges in Knowledge Discovery Systems
Current knowledge discovery systems are armed with many data mining techniques that can be potentially applied to a new problem. However, a system faces a challenge of selecting t...
Mykola Pechenizkiy, Alexey Tsymbal, Seppo Puuronen
BMCBI
2010
178views more  BMCBI 2010»
15 years 2 months ago
Selecting high-dimensional mixed graphical models using minimal AIC or BIC forests
Background: Chow and Liu showed that the maximum likelihood tree for multivariate discrete distributions may be found using a maximum weight spanning tree algorithm, for example K...
David Edwards, Gabriel C. G. de Abreu, Rodrigo Lab...