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» Models and Methods in Comparative Genomics
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BMCBI
2008
111views more  BMCBI 2008»
14 years 10 months ago
Information-based methods for predicting gene function from systematic gene knock-downs
Background: The rapid annotation of genes on a genome-wide scale is now possible for several organisms using high-throughput RNA interference assays to knock down the expression o...
Matthew T. Weirauch, Christopher K. Wong, Alexandr...
BMCBI
2006
186views more  BMCBI 2006»
14 years 10 months ago
Systematic gene function prediction from gene expression data by using a fuzzy nearest-cluster method
Background: Quantitative simultaneous monitoring of the expression levels of thousands of genes under various experimental conditions is now possible using microarray experiments....
Xiaoli Li, Yin-Chet Tan, See-Kiong Ng
BMCBI
2011
14 years 1 months ago
A Novel And Well-Defined Benchmarking Method For Second Generation Read Mapping
Background: Second generation sequencing technologies yield DNA sequence data at ultra high-throughput. Common to most biological applications is a mapping of the reads to an almo...
Manuel Holtgrewe, Anne-Katrin Emde, David Weese, K...
RECOMB
2010
Springer
15 years 1 months ago
MoGUL: Detecting Common Insertions and Deletions in a Population
Abstract. While the discovery of structural variants in the human population is ongoing, most methods for this task assume that the genome is sequenced to high coverage (e.g. 40x),...
Seunghak Lee, Eric Xing, Michael Brudno
ALMOB
2006
155views more  ALMOB 2006»
14 years 10 months ago
A phylogenetic generalized hidden Markov model for predicting alternatively spliced exons
Background: An important challenge in eukaryotic gene prediction is accurate identification of alternatively spliced exons. Functional transcripts can go undetected in gene expres...
Jonathan E. Allen, Steven L. Salzberg