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136
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BMCBI
2005
97views more  BMCBI 2005»
15 years 3 months ago
Sequence variation in ligand binding sites in proteins
Background: The recent explosion in the availability of complete genome sequences has led to the cataloging of tens of thousands of new proteins and putative proteins. Many of the...
Thomas J. Magliery, Lynne Regan
144
Voted
BMCBI
2005
97views more  BMCBI 2005»
15 years 3 months ago
Evolutionary distance estimation and fidelity of pair wise sequence alignment
Background: Evolutionary distances are a critical measure in comparative genomics and molecular evolutionary biology. A simulation study was used to examine the effect of alignmen...
Michael S. Rosenberg
137
Voted
BMCBI
2005
93views more  BMCBI 2005»
15 years 3 months ago
Multiple sequence alignment accuracy and evolutionary distance estimation
Background: Sequence alignment is a common tool in bioinformatics and comparative genomics. It is generally assumed that multiple sequence alignment yields better results than pai...
Michael S. Rosenberg
BMCBI
2005
77views more  BMCBI 2005»
15 years 3 months ago
Combining Affymetrix microarray results
Background: As the use of microarray technology becomes more prevalent it is not unusual to find several laboratories employing the same microarray technology to identify genes re...
John R. Stevens, R. W. Doerge
166
Voted
BMCBI
2005
131views more  BMCBI 2005»
15 years 3 months ago
Regularized Least Squares Cancer Classifiers from DNA microarray data
Background: The advent of the technology of DNA microarrays constitutes an epochal change in the classification and discovery of different types of cancer because the information ...
Nicola Ancona, Rosalia Maglietta, Annarita D'Addab...
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