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BMCBI
2008
145views more  BMCBI 2008»
14 years 12 months ago
The contrasting properties of conservation and correlated phylogeny in protein functional residue prediction
Background: Amino acids responsible for structure, core function or specificity may be inferred from multiple protein sequence alignments where a limited set of residue types are ...
Jonathan R. Manning, Emily R. Jefferson, Geoffrey ...
BMCBI
2008
160views more  BMCBI 2008»
14 years 12 months ago
Feature selection environment for genomic applications
Background: Feature selection is a pattern recognition approach to choose important variables according to some criteria in order to distinguish or explain certain phenomena (i.e....
Fabrício Martins Lopes, David Correa Martin...
BMCBI
2006
101views more  BMCBI 2006»
14 years 11 months ago
SynTReN: a generator of synthetic gene expression data for design and analysis of structure learning algorithms
Background: The development of algorithms to infer the structure of gene regulatory networks based on expression data is an important subject in bioinformatics research. Validatio...
Tim Van den Bulcke, Koen Van Leemput, Bart Naudts,...
BMCBI
2006
117views more  BMCBI 2006»
14 years 11 months ago
Incorporating background frequency improves entropy-based residue conservation measures
Background: Several entropy-based methods have been developed for scoring sequence conservation in protein multiple sequence alignments. High scoring amino acid positions may corr...
Kai Wang, Ram Samudrala
SCFBM
2008
119views more  SCFBM 2008»
14 years 11 months ago
Permutation - based statistical tests for multiple hypotheses
Background: Genomics and proteomics analyses regularly involve the simultaneous test of hundreds of hypotheses, either on numerical or categorical data. To correct for the occurre...
Anyela Camargo, Francisco Azuaje, Haiying Wang, Hu...