In this paper, we present CONTRAlign, an extensible and fully automatic framework for parameter learning and protein pairwise sequence alignment using pair conditional random field...
Sequence alignment is a fundamental problem in the computational biology. Many alignment methods have been proposed in the literature, such as pair-wise sequence alignment (2SA), ...
Chun-Yuan Lin, Chen Tai Huang, Yeh-Ching Chung, Ch...
Background: Automated software tools for multiple alignment often fail to produce biologically meaningful results. In such situations, expert knowledge can help to improve the qua...
Burkhard Morgenstern, Sonja J. Prohaska, Dirk P&ou...
Abstract— Multiple sequence alignment is an important problem in computational biology. A-star is an algorithm that can be used to find exact alignments. We present a simple mod...
Background: Two central problems in computational biology are the determination of the alignment and phylogeny of a set of biological sequences. The traditional approach to this p...