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117
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BMCBI
2004
14 years 11 months ago
2004
Background: Certain protein families are highly conserved across distantly related organisms and belong to large and functionally diverse superfamilies. The patterns of conservati...
103
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BMCBI
2004
14 years 11 months ago
2004
Background: The general problem of RNA secondary structure prediction under the widely used thermodynamic model is known to be NP-complete when the structures considered include a...
BMCBI
2004
14 years 11 months ago
2004
Background: The Split ends (Spen) family are large proteins characterised by N-terminal RNA recognition motifs (RRMs) and a conserved SPOC (Spen paralog and ortholog C-terminal) d...
BMCBI
2004
14 years 11 months ago
2004
Background: The detection of small yet statistically significant differences in gene expression in spotted DNA microarray studies is an ongoing challenge. Meeting this challenge r...
124
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BMCBI
2004
14 years 11 months ago
2004
Background: To identify differentially expressed genes, it is standard practice to test a twosample hypothesis for each gene with a proper adjustment for multiple testing. Such te...