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BMCBI
2008
100views more  BMCBI 2008»
14 years 11 months ago
Hotspot Hunter: a computational system for large-scale screening and selection of candidate immunological hotspots in pathogen p
Background: T-cell epitopes that promiscuously bind to multiple alleles of a human leukocyte antigen (HLA) supertype are prime targets for development of vaccines and immunotherap...
Guanglan Zhang, Asif M. Khan, Kellathur N. Sriniva...
SC
2009
ACM
15 years 6 months ago
Highly scalable genome assembly on campus grids
Bioinformatics researchers need efficient means to process large collections of sequence data. One application of interest, genome assembly, has great potential for parallelizati...
Christopher Moretti, Michael Olson, Scott J. Emric...
BMCBI
2008
145views more  BMCBI 2008»
14 years 11 months ago
Directed acyclic graph kernels for structural RNA analysis
Background: Recent discoveries of a large variety of important roles for non-coding RNAs (ncRNAs) have been reported by numerous researchers. In order to analyze ncRNAs by kernel ...
Kengo Sato, Toutai Mituyama, Kiyoshi Asai, Yasubum...
FPL
2008
Springer
150views Hardware» more  FPL 2008»
15 years 1 months ago
Compiler generated systolic arrays for wavefront algorithm acceleration on FPGAs
Wavefront algorithms, such as the Smith-Waterman algorithm, are commonly used in bioinformatics for exact local and global sequence alignment. These algorithms are highly computat...
Betul Buyukkurt, Walid A. Najjar
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BMCBI
2008
145views more  BMCBI 2008»
14 years 11 months ago
The contrasting properties of conservation and correlated phylogeny in protein functional residue prediction
Background: Amino acids responsible for structure, core function or specificity may be inferred from multiple protein sequence alignments where a limited set of residue types are ...
Jonathan R. Manning, Emily R. Jefferson, Geoffrey ...