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BMCBI
2008
84views more  BMCBI 2008»
15 years 5 months ago
Prediction of specificity-determining residues for small-molecule kinase inhibitors
Background: Designing small-molecule kinase inhibitors with desirable selectivity profiles is a major challenge in drug discovery. A high-throughput screen for inhibitors of a giv...
Daniel R. Caffrey, Elizabeth A. Lunney, Deborah J....
BMCBI
2008
160views more  BMCBI 2008»
15 years 5 months ago
Predicting cancer involvement of genes from heterogeneous data
Background: Systematic approaches for identifying proteins involved in different types of cancer are needed. Experimental techniques such as microarrays are being used to characte...
Ramon Aragues, Chris Sander, Baldo Oliva
BMCBI
2008
136views more  BMCBI 2008»
15 years 5 months ago
An efficient method for the prediction of deleterious multiple-point mutations in the secondary structure of RNAs using suboptim
Background: RNAmute is an interactive Java application which, given an RNA sequence, calculates the secondary structure of all single point mutations and organizes them into categ...
Alexander Churkin, Danny Barash
CORR
2010
Springer
177views Education» more  CORR 2010»
15 years 5 months ago
Supervised Random Walks: Predicting and Recommending Links in Social Networks
Predicting the occurrence of links is a fundamental problem in networks. In the link prediction problem we are given a snapshot of a network and would like to infer which interact...
Lars Backstrom, Jure Leskovec
CN
2007
91views more  CN 2007»
15 years 5 months ago
Improving the quality of alerts and predicting intruder's next goal with Hidden Colored Petri-Net
Intrusion detection systems (IDS) often provide poor quality alerts, which are insufficient to support rapid identification of ongoing attacks or predict an intruder’s next lik...
Dong Yu, Deborah A. Frincke