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» Predicting protein function from domain content
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ICML
2006
IEEE
15 years 10 months ago
A graphical model for predicting protein molecular function
We present a simple statistical model of molecular function evolution to predict protein function. The model description encodes general knowledge of how molecular function evolve...
Barbara E. Engelhardt, Michael I. Jordan, Steven E...
BMCBI
2005
97views more  BMCBI 2005»
14 years 9 months ago
Sequence variation in ligand binding sites in proteins
Background: The recent explosion in the availability of complete genome sequences has led to the cataloging of tens of thousands of new proteins and putative proteins. Many of the...
Thomas J. Magliery, Lynne Regan
TCBB
2010
80views more  TCBB 2010»
14 years 7 months ago
On the Importance of Comprehensible Classification Models for Protein Function Prediction
—The literature on protein function prediction is currently dominated by works aimed at maximizing predictive accuracy, ignoring the important issues of validation and interpreta...
Alex Alves Freitas, Daniela Wieser, Rolf Apweiler
BMCBI
2010
153views more  BMCBI 2010»
14 years 9 months ago
Analysis of substructural variation in families of enzymatic proteins with applications to protein function prediction
Background: Structural variations caused by a wide range of physico-chemical and biological sources directly influence the function of a protein. For enzymatic proteins, the struc...
Drew H. Bryant, Mark Moll, Brian Y. Chen, Viachesl...