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BMCBI
2008
84views more  BMCBI 2008»
13 years 6 months ago
Prediction of specificity-determining residues for small-molecule kinase inhibitors
Background: Designing small-molecule kinase inhibitors with desirable selectivity profiles is a major challenge in drug discovery. A high-throughput screen for inhibitors of a giv...
Daniel R. Caffrey, Elizabeth A. Lunney, Deborah J....
BMCBI
2008
259views more  BMCBI 2008»
13 years 6 months ago
DISCLOSE : DISsection of CLusters Obtained by SEries of transcriptome data using functional annotations and putative transcripti
Background: A typical step in the analysis of gene expression data is the determination of clusters of genes that exhibit similar expression patterns. Researchers are confronted w...
Evert-Jan Blom, Sacha A. F. T. van Hijum, Klaas J....
BMCBI
2010
95views more  BMCBI 2010»
13 years 6 months ago
Quantifying the relationship between sequence and three-dimensional structure conservation in RNA
Background: In recent years, the number of available RNA structures has rapidly grown reflecting the increased interest on RNA biology. Similarly to the studies carried out two de...
Emidio Capriotti, Marc A. Martí-Renom
BMCBI
2008
108views more  BMCBI 2008»
13 years 6 months ago
New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic backgroun
Background: Few genetic factors predisposing to the sporadic form of amyotrophic lateral sclerosis (ALS) have been identified, but the pathology itself seems to be a true multifac...
Silvana Penco, Massimo Buscema, Maria Cristina Pat...
RECOMB
2002
Springer
14 years 6 months ago
Discovering local structure in gene expression data: the order-preserving submatrix problem
This paper concerns the discovery of patterns in gene expression matrices, in which each element gives the expression level of a given gene in a given experiment. Most existing me...
Amir Ben-Dor, Benny Chor, Richard M. Karp, Zohar Y...