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» Systems biology, models, and concurrency
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BMCBI
2006
194views more  BMCBI 2006»
14 years 9 months ago
Novel metaheuristic for parameter estimation in nonlinear dynamic biological systems
Background: We consider the problem of parameter estimation (model calibration) in nonlinear dynamic models of biological systems. Due to the frequent ill-conditioning and multi-m...
Maria Rodriguez-Fernandez, Jose A. Egea, Julio R. ...
JIB
2007
95views more  JIB 2007»
14 years 9 months ago
Integration of constraints documented in SBML, SBO, and the SBML Manual facilitates validation of biological models
The creation of quantitative, simulatable, Systems Biology Markup Language (SBML) models that accurately simulate the system under study is a time-intensive manual process that re...
Allyson L. Lister, Matthew R. Pocock, Anil Wipat
HYBRID
2004
Springer
15 years 2 months ago
Dynamic Partitioning of Large Discrete Event Biological Systems for Hybrid Simulation and Analysis
Abstract. Biological systems involving genetic reactions are large discrete event systems, and often contain certain species that occur in small quantities, and others that occur i...
Natasha A. Neogi
79
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IJIT
2004
14 years 11 months ago
Modeling Biology Inspired Reactive Agents Using X-machines
Recent advances in both the testing and verification of software based on formal specifications of the system to be built have reached a point where the ideas can be applied in a p...
George Eleftherakis, Petros Kefalas, Anna Sotiriad...
TCBB
2008
137views more  TCBB 2008»
14 years 9 months ago
Toward Verified Biological Models
The last several decades have witnessed a vast accumulation of biological data and data analysis. Many of these data sets represent only a small fraction of the system's behav...
Avital Sadot, Jasmin Fisher, Dan Barak, Yishai Adm...