Background: We consider the problem of parameter estimation (model calibration) in nonlinear dynamic models of biological systems. Due to the frequent ill-conditioning and multi-m...
Maria Rodriguez-Fernandez, Jose A. Egea, Julio R. ...
The creation of quantitative, simulatable, Systems Biology Markup Language (SBML) models that accurately simulate the system under study is a time-intensive manual process that re...
Abstract. Biological systems involving genetic reactions are large discrete event systems, and often contain certain species that occur in small quantities, and others that occur i...
Recent advances in both the testing and verification of software based on formal specifications of the system to be built have reached a point where the ideas can be applied in a p...
George Eleftherakis, Petros Kefalas, Anna Sotiriad...
The last several decades have witnessed a vast accumulation of biological data and data analysis. Many of these data sets represent only a small fraction of the system's behav...
Avital Sadot, Jasmin Fisher, Dan Barak, Yishai Adm...