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JCB
2008
90views more  JCB 2008»
14 years 9 months ago
A Simple Model of the Modular Structure of Transcriptional Regulation in Yeast
Resolving the general organizational principles that govern the interactions during transcriptional gene regulation has great relevance for understanding disease progression, biof...
Vladimir Filkov, Nameeta Shah
BMCBI
2008
138views more  BMCBI 2008»
14 years 10 months ago
Systematic identification of yeast cell cycle transcription factors using multiple data sources
Background: Eukaryotic cell cycle is a complex process and is precisely regulated at many levels. Many genes specific to the cell cycle are regulated transcriptionally and are exp...
Wei-Sheng Wu, Wen-Hsiung Li
BIOINFORMATICS
2007
195views more  BIOINFORMATICS 2007»
14 years 10 months ago
Context-dependent clustering for dynamic cellular state modeling of microarray gene expression
Motivation: High-throughput expression profiling allows researchers to study gene activities globally. Genes with similar expression profiles are likely to encode proteins that ma...
Shinsheng Yuan, Ker-Chau Li
BIOSYSTEMS
2007
175views more  BIOSYSTEMS 2007»
14 years 10 months ago
Alternative routes and mutational robustness in complex regulatory networks
Alternative pathways through a gene regulation network connect a regulatory molecule to its (indirect) regulatory target via different intermediate regulators. We here show for tw...
Andreas Wagner, Jeremiah Wright
EUROGP
2007
Springer
104views Optimization» more  EUROGP 2007»
15 years 4 months ago
Code Regulation in Open Ended Evolution
We explore a homeostatic approach to program execution in computer systems: the “concentration” of computation services is regulated according to their fitness. The goal is to...
Lidia Yamamoto