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BMCBI
2007
233views more  BMCBI 2007»
15 years 4 months ago
160-fold acceleration of the Smith-Waterman algorithm using a field programmable gate array (FPGA)
Background: To infer homology and subsequently gene function, the Smith-Waterman (SW) algorithm is used to find the optimal local alignment between two sequences. When searching s...
Isaac T. S. Li, Warren Shum, Kevin Truong
BMCBI
2008
218views more  BMCBI 2008»
15 years 4 months ago
LOSITAN: A workbench to detect molecular adaptation based on a Fst-outlier method
Background: Testing for selection is becoming one of the most important steps in the analysis of multilocus population genetics data sets. Existing applications are difficult to u...
Tiago Antao, Ana Lopes, Ricardo J. Lopes, Albano B...
BMCBI
2008
108views more  BMCBI 2008»
15 years 4 months ago
SPRINT: A new parallel framework for R
Background: Microarray analysis allows the simultaneous measurement of thousands to millions of genes or sequences across tens to thousands of different samples. The analysis of t...
Jon Hill, Matthew Hambley, Thorsten Forster, Murie...
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BMCBI
2008
136views more  BMCBI 2008»
15 years 4 months ago
An efficient method for the prediction of deleterious multiple-point mutations in the secondary structure of RNAs using suboptim
Background: RNAmute is an interactive Java application which, given an RNA sequence, calculates the secondary structure of all single point mutations and organizes them into categ...
Alexander Churkin, Danny Barash
BMCBI
2008
85views more  BMCBI 2008»
15 years 4 months ago
Normalizing biomedical terms by minimizing ambiguity and variability
Background: One of the difficulties in mapping biomedical named entities, e.g. genes, proteins, chemicals and diseases, to their concept identifiers stems from the potential varia...
Yoshimasa Tsuruoka, John McNaught, Sophia Ananiado...
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