259 search results - page 18 / 52 » Using sampling methods to improve binding site predictions |
128
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BMCBI
2006
15 years 15 days ago
2006
Background: A complete understanding of the regulatory mechanisms of gene expression is the next important issue of genomics. Many bioinformaticians have developed methods and alg...
107
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BMCBI
2006
15 years 15 days ago
2006
Background: Many dimeric protein complexes bind cooperatively to families of bipartite nucleic acid sequence elements, which consist of pairs of conserved half-site sequences sepa...
95
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BMCBI
2008
15 years 17 days ago
2008
Background: We have previously described an approach to predicting the substrate specificity of serine-threonine protein kinases. The method, named Predikin, identifies key conser...
108
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BMCBI
2010
15 years 17 days ago
2010
Background: Signal transduction events often involve transient, yet specific, interactions between structurally conserved protein domains and polypeptide sequences in target prote...
105
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BMCBI
2006
15 years 15 days ago
2006
Background: RNA editing is one of several post-transcriptional modifications that may contribute to organismal complexity in the face of limited gene complement in a genome. One f...