13 years 8 days ago
Inference of Differential Equation Models by Multi Expression Programming for Gene Regulatory Networks
This paper presents an evolutionary method for identifying the gene regulatory network from the observed time series data of gene expression using a system of ordinary differential...
Bin Yang, Yuehui Chen, Qingfang Meng
128views Hardware» more  ICES 2010»
13 years 14 days ago
Evolution and Analysis of a Robot Controller Based on a Gene Regulatory Network
Abstract. This paper explores the application of an artificial developmental system (ADS) to the field of evolutionary robotics by investigating the capability of a gene regulatory...
Martin Trefzer, Tüze Kuyucu, Julian F. Miller...
134views more  TSP 2008»
13 years 1 months ago
Effect of Function Perturbation on the Steady-State Distribution of Genetic Regulatory Networks: Optimal Structural Intervention
Abstract--The dynamics of a rule-based gene regulatory network are determined by the regulatory functions in conjunction with whatever probability distributions are involved in net...
Xiaoning Qian, Edward R. Dougherty
13 years 2 months ago
Temporal constraints in the logical analysis of regulatory networks
Starting from the logical description of gene regulatory networks developed by R. Thomas, we introduce an enhanced modelling approach based on timed automata. We obtain a refined ...
Heike Siebert, Alexander Bockmayr
13 years 2 months ago
A Gene Network Model for Developing Cell Lineages
Biological development is a remarkably complex process. A single cell, in an appropriate environment, contains sufficient information to generate a variety of differentiated cell ...
Nicholas Geard, Janet Wiles
157views more  JCP 2006»
13 years 2 months ago
CF-GeNe: Fuzzy Framework for Robust Gene Regulatory Network Inference
Most Gene Regulatory Network (GRN) studies ignore the impact of the noisy nature of gene expression data despite its significant influence upon inferred results. This paper present...
Muhammad Shoaib B. Sehgal, Iqbal Gondal, Laurence ...
153views more  BMCBI 2006»
13 years 2 months ago
Discovery of time-delayed gene regulatory networks based on temporal gene expression profiling
Background: It is one of the ultimate goals for modern biological research to fully elucidate the intricate interplays and the regulations of the molecular determinants that prope...
Xia Li, Shaoqi Rao, Wei Jiang, Chuanxing Li, Yun X...
142views more  BIOINFORMATICS 2006»
13 years 2 months ago
Intervention in a family of Boolean networks
Motivation: Intervention in a gene regulatory network is used to avoid undesirable states, such as those associated with a disease. Several types of intervention have been studied...
Ashish Choudhary, Aniruddha Datta, Michael L. Bitt...
143views more  BMCBI 2007»
13 years 2 months ago
Factor analysis for gene regulatory networks and transcription factor activity profiles
Background: Most existing algorithms for the inference of the structure of gene regulatory networks from gene expression data assume that the activity levels of transcription fact...
Iosifina Pournara, Lorenz Wernisch
110views more  BMCBI 2010»
13 years 2 months ago
TimeDelay-ARACNE: Reverse engineering of gene networks from time-course data by an information theoretic approach
Background: One of main aims of Molecular Biology is the gain of knowledge about how molecular components interact each other and to understand gene function regulations. Using mi...
Pietro Zoppoli, Sandro Morganella, Michele Ceccare...