Residue Contexts: Non-sequential Protein Structure Alignment Using Structural and Biochemical Features

The study of non-sequential alignments, with different connectivity of the aligned fragments in the proteins being compared can offer a more complete picture of the structural, evolutionary and functional relationship between two proteins, than what is possible purely with sequential alignments. The design of techniques for non-sequential protein structure alignment therefore, constitutes an important direction of research. This paper introduces a novel method for non-sequential protein structure alignment involving three principle technical facets: (1) determination of the seed alignments not just by matching features from a single residue or considering well defined regions in the structure such as

• Type: Journal
• Year: 2010
• Where: ISBRA
• Authors: Jay W. Kim, Rahul Singh
• Keywords: Bioinformatics, ISBRA 2010, Non-sequential Protein Structure, Protein, Protein Structure Alignment