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» A new approach to fragment assembly in DNA sequencing
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RECOMB
2001
Springer
14 years 5 months ago
A new approach to fragment assembly in DNA sequencing
For the last twenty years fragment assembly in DNA sequencing followed the "overlap - layout - consensus" paradigm that is used in all currently available assembly tools...
Pavel A. Pevzner, Haixu Tang, Michael S. Waterman
CSB
2005
IEEE
132views Bioinformatics» more  CSB 2005»
13 years 6 months ago
A Fast Shotgun Assembly Heuristic
Genome sequencing opened a new era in genetics allowing the study of genomes at the nucleotide level. However, the chosen method of sequencing produced large numbers of nucleotide...
Christopher Wilks, Sami Khuri
METMBS
2004
162views Mathematics» more  METMBS 2004»
13 years 6 months ago
A Comparison of DNA Fragment Assembly Algorithms
As more research centers embark on sequencing new genomes, the problem of DNA fragment assembly for shotgun sequencing is growing in importance and complexity. Accurate and fast a...
Lishan Li, Sami Khuri
ISMB
1997
13 years 6 months ago
Increasing Consensus Accuracy in DNA Fragment Assemblies by Incorporating Fluorescent Trace Representations
We present a new method for determining the consensus sequence in DNA fragment assemblies. The new method, Trace-Evidence, directly incorporates aligned ABI trace information into...
Carolyn F. Allex, Schuyler F. Baldwin, Jude W. Sha...
CAINE
2008
13 years 6 months ago
Parallel Assembler for Fuzzy Genome Sequence Assembly
Assembly is an NP-Hard problem, which involves comparing fragments that have a time complexity of O(n2 ). This paper presents a parallel approach for sequence assembly. The parall...
Sara Nasser, Adrienne Breland, Frederick C. Harris...