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BIOCOMP
2006
10 years 1 months ago
Membrane Remodeling and Diffusion of Cytochrome C from a Geometrically Idealized Mitochondrial Crista
In healthy eukaryotic cells, mitochondria have an outer membrane that surrounds a complex inner membrane structure [7,8]. Cytochrome c is found in the space between the two membra...
John Manor, Peter Salamon, James Nulton, Joseph Ma...
BIOCOMP
2006
10 years 1 months ago
Reverse Engineering Approach in Molecular Evolution: Simulation and Case Study with Enzyme Proteins
- We developed a method of reverse engineering to compare the behaviour the enzyme proteins with the existing standard concepts. Our work is based on the strong assumption from the...
Sukanya Manna, Cheng-Yuan Liou
BIOCOMP
2006
10 years 1 months ago
The Generalized Topological Overlap Matrix for Detecting Modules in Gene Networks
Systems biologic studies of gene and protein interaction networks have found that these networks are comprised of `modules' (groups of tightly interconnected nodes). Module i...
Andy M. Yip, Steve Horvath
BIOCOMP
2006
10 years 1 months ago
PAC: Progressive Alignment with Consensus Sequences
Computation of multiple sequence alignments is one of the major open problems in computational molecular biology. The purpose of this study was to provide a new method, PAC (Progre...
Ke Liu, Mansur H. Samadzadeh
BIOCOMP
2006
10 years 1 months ago
Parameterized Computation of LCS for Two Sequences
- The problem of finding the longest common subsequence is a well-known optimization problem because of its applications, especially in bioinformatics. In this paper, by applying t...
Yuan Lin, Jeff Jenness, Xiuzhen Huang
BIOCOMP
2006
10 years 1 months ago
The Multi-Node Topological Overlap Measure For Gene Neighborhood Analysis
Defining the neighborhood of an initial set of nodes is an important task in network analysis. For example, we show that the neighborhood of an initial set of brain cancer related ...
Ai Li, Steve Horvath
BIOCOMP
2006
10 years 1 months ago
Using Neural Nets to Estimate Evolutionary Parameters
- The rapid growth in the amount of molecular genetic data being collected will, in many cases, require the development of new analytic methods for the analysis of that data. In th...
Chi-Chiang Lee, Paul Marjoram
BIOCOMP
2006
10 years 1 months ago
A Multi-strategy Approach to Protein Structural Alphabet Design
- The search for structural similarity among proteins can provide valuable insights into their functional mechanisms and their functional relationships. Though the protein 1D seque...
Shih-Yen Ku, Yuh-Jyh Hu
BIOCOMP
2006
10 years 1 months ago
A New Algorithm to Predict the Active Sites Using Amino Acid Vectors and Biochemical features of Surface Patches
: It is a very active research field to predict protein functions and active sites by protein surface patches. It is especially challengeable to predict the active sites by structu...
Sunshin Kim, Chung Rhee, Jungdo Choi, Yong Je Chun...
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