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ICASSP
2011
IEEE
8 years 6 days ago
Biological pathway inference using manifold embedding
Disease occurs due to aberrant modulation of biological pathways. Identification of activated gene pathways from gene expression data is an important problem. In this work, we de...
Arvind Rao, Alfred O. Hero
NAR
2010
123views more  NAR 2010»
8 years 3 months ago
Xenbase: gene expression and improved integration
Xenbase (www.xenbase.org), the model organism database for Xenopus laevis and X. (Silurana) tropicalis, is the principal centralized resource of genomic, development data and comm...
Jeff B. Bowes, Kevin A. Snyder, Erik Segerdell, Ch...
JMLR
2010
125views more  JMLR 2010»
8 years 3 months ago
On utility of gene set signatures in gene expression-based cancer class prediction
Machine learning methods that can use additional knowledge in their inference process are central to the development of integrative bioinformatics. Inclusion of background knowled...
Minca Mramor, Marko Toplak, Gregor Leban, Tomaz Cu...
BMCBI
2011
8 years 3 months ago
Statistical Test of Expression Pattern (STEPath): a new strategy to integrate gene expression data with genomic information in i
Background: In the last decades, microarray technology has spread, leading to a dramatic increase of publicly available datasets. The first statistical tools developed were focuse...
Paolo G. V. Martini, Davide Risso, Gabriele Sales,...
BMCBI
2011
8 years 3 months ago
Motif-guided sparse decomposition of gene expression data for regulatory module identification
Background: Genes work coordinately as gene modules or gene networks. Various computational approaches have been proposed to find gene modules based on gene expression data; for e...
Ting Gong, Jianhua Xuan, Li Chen, Rebecca B. Riggi...
BMCBI
2011
8 years 3 months ago
Appearance frequency modulated gene set enrichment testing
Background: Gene set enrichment testing has helped bridge the gap from an individual gene to a systems biology interpretation of microarray data. Although gene sets are defined a ...
Jun Ma, Maureen A. Sartor, H. V. Jagadish
BMCBI
2010
104views more  BMCBI 2010»
8 years 3 months ago
A systematic study of genome context methods: calibration, normalization and combination
Background: Genome context methods have been introduced in the last decade as automatic methods to predict functional relatedness between genes in a target genome using the patter...
Luciana Ferrer, Joseph M. Dale, Peter D. Karp
ICCS
2009
Springer
8 years 6 months ago
Gene Specific Co-regulation Discovery: An Improved Approach
Abstract. Discovering gene co-regulatory relationships is a new but important research problem in DNA microarray data analysis. The problem of gene specific co-regulation discovery...
Ji Zhang, Qing Liu, Kai Xu 0003
ACIIDS
2010
IEEE
170views Database» more  ACIIDS 2010»
8 years 6 months ago
On the Effectiveness of Gene Selection for Microarray Classification Methods
Microarray data usually contains a high level of noisy gene data, the noisy gene data include incorrect, noise and irrelevant genes. Before Microarray data classification takes pla...
Zhongwei Zhang, Jiuyong Li, Hong Hu, Hong Zhou
RECOMB
2010
Springer
8 years 6 months ago
Detecting Highways of Horizontal Gene Transfer
Abstract. In a horizontal gene transfer (HGT) event a gene is transferred between two species that do not share an ancestor-descendant relationship. Typically, no more than a few g...
Mukul S. Bansal, J. Peter Gogarten, Ron Shamir
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