BMCBI
2008
13 years 4 months ago
2008
Background: By using a standard Support Vector Machine (SVM) with a Sequential Minimal Optimization (SMO) method of training, Na
BMCBI
2008
13 years 4 months ago
2008
Background: A goal of proteomics is to distinguish between states of a biological system by identifying protein expression differences. Liu et al. demonstrated a method to perform...
BMCBI
2008
13 years 4 months ago
2008
Background: Insertions and deletions (indels) represent a common type of sequence variations, which are less studied and pose many important biological questions. Recent research ...
BMCBI
2008
13 years 4 months ago
2008
Background: Modelling proteins with multiple domains is one of the central challenges in Structural Biology. Although homology modelling has successfully been applied for predicti...
BMCBI
2007
13 years 4 months ago
2007
Background: Network methods are increasingly used to represent the interactions of genes and/ or proteins. Genes or proteins that are directly linked may have a similar biological...
BMCBI
2007
13 years 4 months ago
2007
Background: Uncovering cellular roles of a protein is a task of tremendous importance and complexity that requires dedicated experimental work as well as often sophisticated data ...
BMCBI
2007
13 years 4 months ago
2007
Background: Protein aggregation correlates with the development of several debilitating human disorders of growing incidence, such as Alzheimer's and Parkinson's disease...
BMCBI
2007
13 years 4 months ago
2007
Background: Biological sequence repeats arranged in tandem patterns are widespread in DNA and proteins. While many software tools have been designed to detect DNA tandem repeats (...
BMCBI
2007
13 years 4 months ago
2007
Background: Most methods for predicting functional sites in protein 3D structures, rely on information on related proteins and cannot be applied to proteins with no known relative...
BMCBI
2008
13 years 4 months ago
2008
Background: Despite significant improvements in computational annotation of genomes, sequences of abnormal, incomplete or incorrectly predicted genes and proteins remain abundant ...