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BMCBI
2004
167views more  BMCBI 2004»
8 years 11 months ago
Feature selection for splice site prediction: A new method using EDA-based feature ranking
Background: The identification of relevant biological features in large and complex datasets is an important step towards gaining insight in the processes underlying the data. Oth...
Yvan Saeys, Sven Degroeve, Dirk Aeyels, Pierre Rou...
BMCBI
2004
141views more  BMCBI 2004»
8 years 11 months ago
Estimates of statistical significance for comparison of individual positions in multiple sequence alignments
Background: Profile-based analysis of multiple sequence alignments (MSA) allows for accurate comparison of protein families. Here, we address the problems of detecting statistical...
Ruslan Sadreyev, Nick V. Grishin
BMCBI
2004
94views more  BMCBI 2004»
8 years 11 months ago
The MB2 gene family of Plasmodium species has a unique combination of S1 and GTP-binding domains
Background: Identification and characterization of novel Plasmodium gene families is necessary for developing new anti-malarial therapeutics. The products of the Plasmodium falcip...
Lisa C. Romero, Thanh Vinh Nguyen, Benoit Deville,...
BMCBI
2004
136views more  BMCBI 2004»
8 years 11 months ago
A SNP-centric database for the investigation of the human genome
Background: Single Nucleotide Polymorphisms (SNPs) are an increasingly important tool for genetic and biomedical research. Although current genomic databases contain information o...
Alberto Riva, Isaac S. Kohane
BMCBI
2004
97views more  BMCBI 2004»
8 years 11 months ago
Global features of sequences of bacterial chromosomes, plasmids and phages revealed by analysis of oligonucleotide usage pattern
Background: Oligonucleotide frequencies were shown to be conserved signatures for bacterial genomes, however, the underlying constraints have yet not been resolved in detail. In t...
Oleg N. Reva, Burkhard Tümmler
BMCBI
2004
156views more  BMCBI 2004»
8 years 11 months ago
GeneXplorer: an interactive web application for microarray data visualization and analysis
Background: When publishing large-scale microarray datasets, it is of great value to create supplemental websites where either the full data, or selected subsets corresponding to ...
Christian A. Rees, Janos Demeter, John C. Matese, ...
BMCBI
2004
151views more  BMCBI 2004»
8 years 11 months ago
Design, implementation and evaluation of a practical pseudoknot folding algorithm based on thermodynamics
Background: The general problem of RNA secondary structure prediction under the widely used thermodynamic model is known to be NP-complete when the structures considered include a...
Jens Reeder, Robert Giegerich
BMCBI
2004
208views more  BMCBI 2004»
8 years 11 months ago
Hybrid clustering for microarray image analysis combining intensity and shape features
Background: Image analysis is the first crucial step to obtain reliable results from microarray experiments. First, areas in the image belonging to single spots have to be identif...
Jörg Rahnenführer, Daniel Bozinov
BMCBI
2004
123views more  BMCBI 2004»
8 years 11 months ago
A two-way interface between limited Systems Biology Markup Language and R
Background: Systems Biology Markup Language (SBML) is gaining broad usage as a standard for representing dynamical systems as data structures. The open source statistical programm...
Tomas Radivoyevitch
BMCBI
2004
86views more  BMCBI 2004»
8 years 11 months ago
A computer simulation analysis of the accuracy of partial genome sequencing and restriction fragment analysis in estimating gene
Background: Determination of genetic relatedness among microorganisms provides information necessary for making inferences regarding phylogeny. However, there is little informatio...
Baozhen Qiao, Ronald M. Weigel
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