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BMCBI
2004
124views more  BMCBI 2004»
8 years 11 months ago
The Molecular Pages of the mesotelencephalic dopamine consortium (DopaNet)
Background: DopaNet http://www.dopanet.org is a Systems Biology initiative that aims to investigate precisely and quantitatively all the aspects of neurotransmission in a specific...
Nicolas Le Novère, Marco Donizelli
BMCBI
2004
91views more  BMCBI 2004»
8 years 11 months ago
Improved hit criteria for DNA local alignment
The hit criterion is a key component of heuristic local alignment algorithms. It specifies a class of patterns assumed to witness a potential similarity, and this choice is decisi...
Laurent Noé, Gregory Kucherov
BMCBI
2004
123views more  BMCBI 2004»
8 years 11 months ago
galaxieEST: addressing EST identity through automated phylogenetic analysis
Background: Research involving expressed sequence tags (ESTs) is intricately coupled to the existence of large, well-annotated sequence repositories. Comparatively complete and sa...
R. Henrik Nilsson, Balaji Rajashekar, Karl-Henrik ...
BMCBI
2004
177views more  BMCBI 2004»
8 years 11 months ago
Gapped alignment of protein sequence motifs through Monte Carlo optimization of a hidden Markov model
Background: Certain protein families are highly conserved across distantly related organisms and belong to large and functionally diverse superfamilies. The patterns of conservati...
Andrew F. Neuwald, Jun S. Liu
BMCBI
2004
105views more  BMCBI 2004»
8 years 11 months ago
eL-DASionator: an LDAS upload file generator
Background: The Distributed Annotation System (DAS) allows merging of DNA sequence annotations from multiple sources and provides a single annotation view. A straightforward way t...
Vincent Nègre, Christoph Grunau
BMCBI
2004
92views more  BMCBI 2004»
8 years 11 months ago
BioBuilder as a database development and functional annotation platform for proteins
Background: The explosion in biological information creates the need for databases that are easy to develop, easy to maintain and can be easily manipulated by annotators who are m...
J. Daniel Navarro, Naveen Talreja, Suraj Peri, B. ...
BMCBI
2004
158views more  BMCBI 2004»
8 years 11 months ago
A novel Mixture Model Method for identification of differentially expressed genes from DNA microarray data
Background: The main goal in analyzing microarray data is to determine the genes that are differentially expressed across two types of tissue samples or samples obtained under two...
Kayvan Najarian, Maryam Zaheri, Ali Ajdari Rad, Si...
BMCBI
2004
84views more  BMCBI 2004»
8 years 11 months ago
Comparison of computational methods for identifying translation initiation sites in EST data
Background: Expressed Sequence Tag (EST) sequences are generally single-strand, single-pass sequences, only 200
Afshin Nadershahi, Scott C. Fahrenkrug, Lynda B. M...
BMCBI
2004
120views more  BMCBI 2004»
8 years 11 months ago
Clustering under the line graph transformation: application to reaction network
Background: Many real networks can be understood as two complementary networks with two kind of nodes. This is the case of metabolic networks where the first network has chemical ...
Jose C. Nacher, Nobuhisa Ueda, Takuji Yamada, Mino...
BMCBI
2004
117views more  BMCBI 2004»
8 years 11 months ago
Cancer characterization and feature set extraction by discriminative margin clustering
Background: A central challenge in the molecular diagnosis and treatment of cancer is to define a set of molecular features that, taken together, distinguish a given cancer, or ty...
Kamesh Munagala, Robert Tibshirani, Patrick O. Bro...
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