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RECOMB
2007
Springer
9 years 6 months ago
Selecting Genomes for Reconstruction of Ancestral Genomes
It is often impossible to sequence all descendent genomes to reconstruct an ancestral genome. In addition, more genomes do not necessarily give a higher accuracy for the reconstruc...
Guoliang Li, Jian Ma, Louxin Zhang
RECOMB
2007
Springer
9 years 6 months ago
Learning Gene Regulatory Networks via Globally Regularized Risk Minimization
Learning the structure of a gene regulatory network from time-series gene expression data is a significant challenge. Most approaches proposed in the literature to date attempt to ...
Yuhong Guo, Dale Schuurmans
RECOMB
2007
Springer
9 years 6 months ago
How to Achieve an Equivalent Simple Permutation in Linear Time
The problem of Sorting signed permutations by reversals is a well studied problem in computational biology. The first polynomial time algorithm was presented by Hannenhalli and Pev...
Simon Gog, Martin Bader
RECOMB
2007
Springer
9 years 6 months ago
Improving Inversion Median Computation Using Commuting Reversals and Cycle Information
In the past decade, genome rearrangements have attracted increasing attention from both biologists and computer scientists as a new type of data for phylogenetic analysis. Methods ...
William Arndt, Jijun Tang
RECOMB
2007
Springer
9 years 6 months ago
Multi-break Rearrangements: From Circular to Linear Genomes
Multi-break rearrangements break a genome into multiple fragments and further glue them together in a new order. While 2break rearrangements represent standard reversals, fusions, ...
Max A. Alekseyev
RECOMB
2007
Springer
9 years 6 months ago
Minimizing and Learning Energy Functions for Side-Chain Prediction
Abstract. Side-chain prediction is an important subproblem of the general protein folding problem. Despite much progress in side-chain prediction, performance is far from satisfact...
Chen Yanover, Ora Schueler-Furman, Yair Weiss
RECOMB
2007
Springer
9 years 6 months ago
An Efficient and Accurate Graph-Based Approach to Detect Population Substructure
Currently, large-scale projects are underway to perform whole genome disease association studies. Such studies involve the genotyping of hundreds of thousands of SNP markers. One o...
Srinath Sridhar, Satish Rao, Eran Halperin
RECOMB
2007
Springer
9 years 6 months ago
Pairwise Global Alignment of Protein Interaction Networks by Matching Neighborhood Topology
We describe an algorithm, IsoRank, for global alignment of two protein-protein interaction (PPI) networks. IsoRank aims to maximize the overall match between the two networks; in c...
Rohit Singh, Jinbo Xu, Bonnie Berger
RECOMB
2007
Springer
9 years 6 months ago
GIMscan: A New Statistical Method for Analyzing Whole-Genome Array CGH Data
Genetic instability represents an important type of biological markers for cancer and many other diseases. Array Comparative Genome Hybridization (aCGH) is a high-throughput cytoge...
Yanxin Shi, Fan Guo, Wei Wu, Eric P. Xing
RECOMB
2007
Springer
9 years 6 months ago
A Feature-Based Approach to Modeling Protein-DNA Interactions
Transcription factor (TF) binding to its DNA target site is a fundamental regulatory interaction. The most common model used to represent TF binding specificities is a position spe...
Eilon Sharon, Eran Segal
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