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RECOMB
2007
Springer
9 years 10 months ago
Design of Compact, Universal DNA Microarrays for Protein Binding Microarray Experiments
Our group has recently developed a compact, universal protein binding microarray (PBM) that can be used to determine the binding preferences of transcription factors (TFs) [1]. Thi...
Anthony A. Philippakis, Aaron M. Qureshi, Michael ...
RECOMB
2007
Springer
9 years 10 months ago
Rearrangements in Genomes with Centromeres Part I: Translocations
A centromere is a special region in the chromosome that plays a vital role during cell division. Every new chromosome created by a genome rearrangement event must have a centromere...
Michal Ozery-Flato, Ron Shamir
RECOMB
2007
Springer
9 years 10 months ago
Protein Conformational Flexibility Analysis with Noisy Data
Abstract. Protein conformational changes play a critical role in biological functions such as ligand-protein and protein-protein interactions. Due to the noise in structural data, ...
Anshul Nigham, David Hsu
RECOMB
2007
Springer
9 years 10 months ago
Peptide Retention Time Prediction Yields Improved Tandem Mass Spectrum Identification for Diverse Chromatography Conditions
Most tandem mass spectrum identification algorithms use information only from the final spectrum, ignoring precursor information such as peptide retention time (RT). Efforts to exp...
Aaron A. Klammer, Xianhua Yi, Michael J. MacCoss, ...
RECOMB
2007
Springer
9 years 10 months ago
A Bayesian Model That Links Microarray mRNA Measurements to Mass Spectrometry Protein Measurements
Abstract. An important problem in biology is to understand correspondences between mRNA microarray levels and mass spectrometry peptide counts. Recently, a compendium of mRNA expre...
Anitha Kannan, Andrew Emili, Brendan J. Frey
RECOMB
2007
Springer
9 years 10 months ago
Free Energy Estimates of All-Atom Protein Structures Using Generalized Belief Propagation
We present a technique for approximating the free energy of protein structures using Generalized Belief Propagation (GBP). The accuracy and utility of these estimates are then demo...
Hetunandan Kamisetty, Eric P. Xing, Christopher Ja...
RECOMB
2007
Springer
9 years 10 months ago
Beyond Galled Trees - Decomposition and Computation of Galled Networks
Reticulate networks are a type of phylogenetic network that are used to represent reticulate evolution involving hybridization, horizontal gene transfer or recombination. The simpl...
Daniel H. Huson, Tobias H. Klöpper
RECOMB
2007
Springer
9 years 10 months ago
Comparative Analysis of Spatial Patterns of Gene Expression in Drosophila melanogaster Imaginal Discs
Determining the precise spatial extent of expression of genes across different tissues, along with knowledge of the biochemical function of the genes is critical for understanding ...
Cyrus L. Harmon, Parvez Ahammad, Ann Hammonds, Ric...
RECOMB
2007
Springer
9 years 10 months ago
Network Motif Discovery Using Subgraph Enumeration and Symmetry-Breaking
The study of biological networks and network motifs can yield significant new insights into systems biology. Previous methods of discovering network motifs ? network-centric subgra...
Joshua A. Grochow, Manolis Kellis
RECOMB
2007
Springer
9 years 10 months ago
An Efficient Method for Dynamic Analysis of Gene Regulatory Networks and in silico Gene Perturbation Experiments
With the increasing availability of experimental data on gene-gene and protein-protein interactions, modeling of gene regulatory networks has gained a special attention lately. To ...
Abhishek Garg, Ioannis Xenarios, Luis Mendoza, Gio...
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