BMCBI
2005
13 years 5 months ago
2005
Background: In a genetic interaction, the phenotype of a double mutant differs from the combined phenotypes of the underlying single mutants. When the single mutants have no growt...
BMCBI
2005
13 years 5 months ago
2005
Background: Many cutting-edge microarray analysis tools and algorithms, including commonly used limma and affy packages in Bioconductor, need sophisticated knowledge of mathematic...
BMCBI
2005
13 years 5 months ago
2005
Background: Biological Mass Spectrometry is used to analyse peptides and proteins. A mass spectrum generates a list of measured mass to charge ratios and intensities of ionised pe...
BMCBI
2005
13 years 5 months ago
2005
Background: Peptide Mass Fingerprinting (PMF) is a widely used mass spectrometry (MS) method of analysis of proteins and peptides. It relies on the comparison between experimental...
BMCBI
2005
13 years 5 months ago
2005
Background: Biological processes are carried out by coordinated modules of interacting molecules. As clustering methods demonstrate that genes with similar expression display incr...
BMCBI
2005
13 years 5 months ago
2005
Background: Profile hidden Markov model (HMM) techniques are among the most powerful methods for protein homology detection. Yet, the critical features for successful modelling ar...
BMCBI
2005
13 years 5 months ago
2005
Background: The degree to which conventional DNA sequencing techniques will be successful for highly repetitive genomes is unclear. Investigators are therefore considering various...
BMCBI
2005
13 years 5 months ago
2005
Background: To study complex biochemical reaction networks in living cells researchers more and more rely on databases and computational methods. In order to facilitate computatio...
BMCBI
2005
13 years 5 months ago
2005
Background: The integration of genomic information with quantitative experimental data is a key component of systems biology. An increasing number of microbial genomes are being s...