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BMCBI
2005
95views more  BMCBI 2005»
8 years 5 months ago
Commensurate distances and similar motifs in genetic congruence and protein interaction networks in yeast
Background: In a genetic interaction, the phenotype of a double mutant differs from the combined phenotypes of the underlying single mutants. When the single mutants have no growt...
Ping Ye, Brian D. Peyser, Forrest A. Spencer, Joel...
BMCBI
2005
86views more  BMCBI 2005»
8 years 5 months ago
WebArray: an online platform for microarray data analysis
Background: Many cutting-edge microarray analysis tools and algorithms, including commonly used limma and affy packages in Bioconductor, need sophisticated knowledge of mathematic...
Xiaoqin Xia, Michael McClelland, Yipeng Wang
BMCBI
2005
128views more  BMCBI 2005»
8 years 5 months ago
Transformation and other factors of the peptide mass spectrometry pairwise peak-list comparison process
Background: Biological Mass Spectrometry is used to analyse peptides and proteins. A mass spectrum generates a list of measured mass to charge ratios and intensities of ionised pe...
Witold E. Wolski, Maciej Lalowski, Peter Martus, R...
BMCBI
2005
147views more  BMCBI 2005»
8 years 5 months ago
Calibration of mass spectrometric peptide mass fingerprint data without specific external or internal calibrants
Background: Peptide Mass Fingerprinting (PMF) is a widely used mass spectrometry (MS) method of analysis of proteins and peptides. It relies on the comparison between experimental...
Witold E. Wolski, Maciej Lalowski, Peter Jungblut,...
BMCBI
2005
113views more  BMCBI 2005»
8 years 5 months ago
Systematic survey reveals general applicability of "guilt-by-association" within gene coexpression networks
Background: Biological processes are carried out by coordinated modules of interacting molecules. As clustering methods demonstrate that genes with similar expression display incr...
Cecily J. Wolfe, Isaac S. Kohane, Atul J. Butte
BMCBI
2005
152views more  BMCBI 2005»
8 years 5 months ago
Improved profile HMM performance by assessment of critical algorithmic features in SAM and HMMER
Background: Profile hidden Markov model (HMM) techniques are among the most powerful methods for protein homology detection. Yet, the critical features for successful modelling ar...
Markus Wistrand, Erik L. L. Sonnhammer
BMCBI
2005
114views more  BMCBI 2005»
8 years 5 months ago
Extension of Lander-Waterman theory for sequencing filtered DNA libraries
Background: The degree to which conventional DNA sequencing techniques will be successful for highly repetitive genomes is unclear. Investigators are therefore considering various...
Michael C. Wendl, W. Bradley Barbazuk
BMCBI
2005
156views more  BMCBI 2005»
8 years 5 months ago
A new dynamical layout algorithm for complex biochemical reaction networks
Background: To study complex biochemical reaction networks in living cells researchers more and more rely on databases and computational methods. In order to facilitate computatio...
Katja Wegner, Ursula Kummer
BMCBI
2005
110views more  BMCBI 2005»
8 years 5 months ago
ProGenExpress: Visualization of quantitative data on prokaryotic genomes
Background: The integration of genomic information with quantitative experimental data is a key component of systems biology. An increasing number of microbial genomes are being s...
Michael Watson
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