162
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BMCBI
2011
14 years 8 months ago
2011
Background: In 2004, we presented a web resource for stimulating the search for novel RNAs, RNA-As-Graphs (RAG), which classified, catalogued, and predicted RNA secondary structur...
167
Voted
BMCBI
2011
14 years 8 months ago
2011
Background: In genetic transcription research, gene expression is typically reported in a test sample relative to a reference sample. Laboratory assays that measure gene expressio...
165
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BMCBI
2011
14 years 8 months ago
2011
Background: Automatic quantification of neuronal morphology from images of fluorescence microscopy plays an increasingly important role in high-content screenings. However, there ...
176
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BMCBI
2011
14 years 8 months ago
2011
Background: Copy number data are routinely being extracted from genome-wide association study chips using a variety of software. We empirically evaluated and compared four freely-...
203
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BMCBI
2011
14 years 8 months ago
2011
Background: The Smith-Waterman algorithm for local sequence alignment is more sensitive than heuristic methods for database searching, but also more time-consuming. The fastest ap...
172
Voted
BMCBI
2011
14 years 8 months ago
2011
Background: Statistical methods for ranking differentially expressed genes (DEGs) from gene expression data should be evaluated with regard to high sensitivity, specificity, and r...
171
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BMCBI
2011
14 years 8 months ago
2011
Background: While there are many methods for predicting protein-protein interaction, very few can determine the specific site of interaction on each protein. Characterization of t...
174
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BMCBI
2011
14 years 8 months ago
2011
Background: Estimation of allele frequency is of fundamental importance in population genetic analyses and in association mapping. In most studies using next-generation sequencing...
152
Voted
BMCBI
2011
14 years 8 months ago
2011
Background: Automated genotype calling in tetraploid species was until recently not possible, which hampered genetic analysis. Modern genotyping assays often produce two signals, ...
159
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BMCBI
2011
14 years 8 months ago
2011
Background: Patterns of genome-wide methylation vary between tissue types. For example, cancer tissue shows markedly different patterns from those of normal tissue. In this paper ...