181
click to vote
BMCBI
2011
14 years 8 months ago
2011
Background: The analysis of gene expression from time series underpins many biological studies. Two basic forms of analysis recur for data of this type: removing inactive (quiet) ...
158
click to vote
BMCBI
2011
14 years 8 months ago
2011
Background: Elucidating the exact relationship between gene copy number and expression would enable identification of regulatory mechanisms of abnormal gene expression and biologi...
193
click to vote
BMCBI
2011
14 years 8 months ago
2011
Background: Constraint-based approaches facilitate the prediction of cellular metabolic capabilities, based, in turn on predictions of the repertoire of enzymes encoded in the gen...
179
click to vote
BMCBI
2011
14 years 8 months ago
2011
Background: The Biodiversity Heritage Library (BHL) is a large digital archive of legacy biological literature, comprising over 31 million pages scanned from books, monographs, an...
177
click to vote
BMCBI
2011
14 years 8 months ago
2011
Background: Conotoxin has been proven to be effective in drug design and could be used to treat various disorders such as schizophrenia, neuromuscular disorders and chronic pain. ...
191
click to vote
BMCBI
2011
14 years 8 months ago
2011
Background: The secondary structure of RNA molecules is intimately related to their function and often more conserved than the sequence. Hence, the important task of searching dat...
171
click to vote
BMCBI
2011
14 years 8 months ago
2011
Background: G protein-coupled receptors (GPCRs) transduce a wide variety of extracellular signals to within the cell and therefore have a key role in regulating cell activity and ...
154
click to vote
BMCBI
2011
14 years 8 months ago
2011
Background: Second generation sequencing technologies yield DNA sequence data at ultra high-throughput. Common to most biological applications is a mapping of the reads to an almo...
172
click to vote
BMCBI
2011
14 years 8 months ago
2011
Background: Graphical models of network associations are useful for both visualizing and integrating multiple types of association data. Identifying modules, or groups of function...
163
click to vote
BMCBI
2011
14 years 8 months ago
2011
Background: Using microarray and sequencing platforms, a large number of copy number variations (CNVs) have been identified in humans. In practice, because our human genome is a d...